Monday 19 March 2012

IPHREHAB: Can Creatine be termed as a Steroid?

IPHREHAB

Can Creatine be termed as a Steroid?

Creatine is a nitrogenous organic acid occurring naturally in all vertebrates. Creatine helps to supply energy to muscle and nerve cells. The body manufactures, stores and uses creatine for pursuits which require bursts of energy – like running at a high speed. Unfortunately creatine reserves within the body can only supply energy from creatine for a very short period of time.

Creatine has quite often been likened to anabolic steroids, because it provides the user with higher amounts of energy and increases lean muscle mass. But nothing could be further from the truth. Though both anabolic steroids and creatine enhance performance, and both are ingested as sports supplements, the basic difference lies in the chemical structure of the two. Anabolic steroids like testosterone are hormones, while creatine is a protein available in the body.

Chemical Structure of Creatine Mono hydrate

 
When this is compared to testosterone – one of the most popular anabolic steroids, distinct differences can be found.

 
From the structures it is apparent that the linear bonded creatine is different from the helical testosterone. 

Steroids are of two varieties – anabolic steroids promote generation of new cells and promote growth. Androgynous steroids are responsible for exerting masculine features in the body, like growth of facial hair and deepening of the voice. Most steroids however have both anabolic and androgynous capabilities. For example testosterone promotes growth and masculine features in males. This is vastly different from the effects of creatine, which in essence, increases ones energy to perform. Thus, a bodybuilder on creatine becomes capable of running an extra mile, or lifting extra weight due to the excess energy within his body. This in turn, helps him develop his body quicker. Creatine also has an effect of absorbing water, which increases the water mass of muscles.

Creatine can be classified as a dietary health supplement, as one can consume, theoretically, enough creatine rich food – like red meat, to substitute supplementation. This cannot be done in the case of steroids, which are released within the human body by specific glands, at specific ages and in specific quantities. To amplify the effects of steroids, they have to be ingested through supplements.

Creatine can be said to be closer to vitamins than steroids or hormones. Since creatine is an amino acid(as can be understood from its structure) it is similar to glutamine, and arginine – both used to enhance performance. Creatine supporters have even claimed that taking creatine is not any more unnatural than taking a multivitamin.

Creatine may not be as harmful for the body as steroids are, but studies on the effect of creatine on the body are limited. According to independent reports, organizations like the WTA, ITF, NBA and FIFA are seeking to ban the use of creatine among their athletes. The International Olympic Committee does not specifically ban creatine but it does ban the use of ergogenic acids. Creatine falls under this group due to its performance enhancing capacities.

Thus, a consultation with a physician is imperative before taking creatine, to verify dosage and length of time one should use creatine.

IPHREHAB :How is Creatine Different from Steroids?

IPHREHAB
How is Creatine Different from Steroids?


QUESTION:
16-year-old boy is really into sports. He's on the football team and baseball team, and he spends a lot of time working out and lifting weights with his friends. Recently, he started taking creatine to build muscle and improve his performance. I was alarmed when I found out, but he assures me that creatine is natural and safe. Is this true? What's the difference between creatine and steroids?

Performance-enhancing supplements like creatine, which is sold over-the-counter, are gaining fast popularity among middle school and high school students, even though they are not recommended for children under 18. In a recently study by the American Academy of Pediatrics, 44 percent of high school seniors admitted using creatine. Creatine is a naturally occurring substance that is found in low doses in foods. Proponents say it can safely add muscle and improve strength and endurance, but there is serious concern among doctors about the possible long-term effects of taking it in high doses. Furthermore, because creatine is marketed as a supplement, it isn't held to the strict standards of the Food and Drug Administration. It is also, like steroids, banned from athletic organizations like the NFL, NCAA, and the International Olympic Committee.

Anabolic steroids are also used by athletes to enhance performance, but these are extremely powerful and dangerous drugs that help to build muscle tissue by acting like the male hormone testosterone. Relying on anabolic steroids to improve athletic ability is not only illegal, it can be extremely harmful, especially for teenagers. Steroids can have an extreme effect on stunting growth.

 Other side effects include:
• Severe acne
• Baldness
• Sleep problems
• Headaches
• Nausea and vomiting
• Diarrhea
• High blood pressure, heart disease and strokes
• Liver damage
• Aggressive, violent behavior
• Severe mood swings (also depression and anxiety attacks)
• Hallucinations and paranoia

Additionally, steroids cause males to produce less of their own testosterone, which can result in impotence, gynecomastia (increased breast size) and reduced sperm count. In females, steroids can lead to reduced breast size, deeper voice, increased facial and body hair, and menstrual problems.

Remember, athletic ability depends on more than just muscle mass. Genetics, age, diet, training, dedication, and perserverance all play a part in how a young adult plays sports. Using steroids or supplements is not only cheating, it can cause numerous health problems. Until safety can be established, I would discourage your son from taking creatine.

IPHREHAB: Dengue Fever Remedy

IPHREHAB

Dengue Fever Remedy

I would like to share this interesting discovery from a classmate's son who has just recovered from dengue fever. Apparently, his son was in the critical stage at the ICU when his blood platelet count drops to 15 after 15 liters of blood transfusion.

His father was so worried that he seeks another friend's recommendation and his son was saved. He confessed to me that he gave his son raw juice of the papaya leaves. From a platelet count of 45 after 20 liters of blood transfusion, and after drinking the raw papaya leaf juice, his platelet count jumps instantly to 135.
 Even the doctors and nurses were surprised. After the second day he was discharged. So he asked me to pass this good news around.
Accordingly it is raw papaya leaves, 2pcs just cleaned and pound and squeeze with filter cloth. You will only get one tablespoon per leaf.. So two tablespoon per serving once a day. Do not boil or cook or rinse with hot water, it will lose its strength.
 Only the leafy part and no stem or sap. It is very bitter and you have to swallow it like "Won Low Kat". But it works.

*Papaya Juice - Cure for Dengue*
You may have heard this elsewhere but if not I am glad to inform you that papaya juice is a natural cure for dengue fever. As dengue fever is rampant now, I think it's good to share this with all.

A friend of mine had dengue last year.. It was a very serious situation for her as her platelet count had dropped to 28,000 after 3 days in hospital and water has started to fill up her lung. She had difficulty in breathing. 
She was only 32-year old. Doctor says there's no cure for dengue. We just have to wait for her body immune system to build up resistance against dengue and fight its own battle. She already had 2 blood transfusion and all of us were praying very hard as her platelet continued to drop since the first day she was admitted.

Fortunately her mother-in-law heard that papaya juice would help to reduce the fever and got some papaya leaves, pounded them and squeeze the juice out for her. The next day, her platelet count started to increase, her fever subside. 
We continued to feed her with papaya juice and she recovered after 3 days!!!

Amazing but it's true. It's believed one's body would be overheated when one is down with dengue and that also caused the patient to have fever papaya juice has cooling effect. Thus, it helps to reduce the level of heat in one's body, thus the fever will go away.
 I found that it's also good when one is having sore throat or suffering from heat.

Please spread the news about this as lately there are many dengue cases. It's great if such natural cure could help to ease the sufferings of dengue patients.

Furthermore it's so easily available.
Blend them and squeeze the juice! It's simple and miraculously effective!!

Sunday 11 March 2012

IPHREHAB: Premature Ejaculation / PE AND SEXUAL DYSFUNCTION

IPHREHAB
Premature Ejaculation / PE

Premature ejaculation or PE as it is commonly known is a sexual dysfunction affecting young men aged below 40 years. It could be simply explained by saying that it is the male climax or ejaculation occurring before either of the partners is ready for it. In colloquial terms it could be described as ‘coming within six thrusts’ or ‘coming within two minutes.’

Greek mythology called it ejaculatio praecox. The Greek God of fire, while in pursuit of the goddess Athena, dropped his seed on her leg and thus was conceived the God Erichthonius , King of Athens.5

It is very often thought to be psychological in origin, where a man who is very anxious or has oversensitive genitals ejaculates before penetration or too soon after penetration, and that it does not yield the desired satisfaction to the couple. When such a situation leads to frustration, lack of enjoyment from sex, and finally depression and lack of self-esteem, it is deemed to be a case of premature ejaculation. It would not be an understatement to state that premature ejaculation can be a leading cause for broken relationships. 

The condition has been linked to instances of abuse or traumatic experiences related to sex in childhood or anxious individuals. It could at times be secondary to hormonal problems or problems related to the prostate gland. 

A detailed history of the man’s sex habits, prior sexual trysts, as well as that of the partner must be elicited while treating a couple affected by premature ejaculation.

Sometimes, it could be an instance of the female partner taking a rather too long time to climax, or not climaxing at all, as opposed to a man ejaculating prematurely. An examination of the male usually does not reveal any abnormality.

Treatment lies in both partners understanding the problem, and approaching it in a relaxed manner. Various exercises, positions and maneuvers are recommended to delay the ejaculation for that wee bit longer.

Medications useful for this condition are the anti-depressants, which actually delay ejaculation as a side effect and not as a primary effect. Local anesthetic creams are available which when applied over the penis, numb it and thereby delay the stimulation and ejaculation process.

Though research is on for better drugs, nothing can surpass an easy attitude, understanding stance and patient approach to this problem. Healing oneself of old emotional scars, perhaps with the help of a psychologist also goes a long way in overcoming this problem.

Saturday 10 March 2012

IPHREHAB:How to Eat to Increase Your Testosterone

IPHREHAB
How to Eat to Increase Your Testosterone


Aging men and bodybuilders wishing to increase their testosterone levels often try various herbs and pills. However, too many of them ignore the impact of the most powerful "supplement" of all -- food.

A healthy diet is one of the most effective ways for men of all ages to naturally and safely increase their testosterone. Although nutritionists and medical researchers differ on the details, there's increasing evidence the high testosterone diet is the diet men (and women) ate for hundreds of thousands of years before the invention of agriculture -- large quantities of lean meat and fish, vegetables, and nuts.
Dr. Weston Price and Dr. Loren Cordain studied hunting gatherer societies around the world and found they all relied on animal protein. And their members did not suffer from obesity, heart disease, or cancer.

You increase your blood sugar levels when you eat lots of starchy and sugar carbohydrate foods -- all food with what's known as a high Glycemic Load. This forces the pancreas to release insulin.
The more sugar and starches you eat, the more sugar in your blood. The more sugar in your blood, the more insulin your pancreas releases. The more insulin release, the more it inhibits your cyclic AMP, reducing your testosterone.

Not only that, but insulin instructs your cells to store excess carbohydrates as fat. When your insulin levels are high it's nearly impossible to burn stored fat. So excess insulin increases your body's stores of fat. And fat cells produce inflammatory biochemicals that inhibit the pituitary gland's signals to the testes to create more testosterone.

The more sugar and starchy foods you eat, the higher your levels of insulin and the more fat your body stores, reducing your testosterone. Therefore, to increase or maintain your levels of testosterone, reduce or eliminate sugar and starchy foods from your diet. Eat protein, vegetables, nuts, and fruit in moderation -- just like our "primitive" ancestors.

IPHREHAB: NUTRITION IN MERATHON

IPHREHAB
NUTRITION IN MERATHON


1. Keep hydrated.
Drink eight glasses of water per day, and make sure to keep drinking while exercising.


2. Decrease or eliminate junk food.
It supplies empty calories, excess fat and sodium, sugar and food additives.


3. Feed your muscles.
They need energy to work, and their main energy source is glycogen. Carbohydrates are your best source of glycogen.


4. Eat 5 to 6 grams of carbohydrates per kilogram of body weight
To supply adequate glycogen to muscles.


5. Choose healthy sources of carbohydrates.
Eat fruits, salads, pasta, cereals and whole-grain breads. They not only provide carbohydrates, but are packed with fibres, vitamins and minerals.


6. Check with a professional trainer or nutritionist to assess whether you need extra protein.
If you are training vigorously, extra protein may be worth considering. The added amount is usually small, even for professional athletes.


7. Eat a healthy, well-balanced diet
The USDA's (United States Department of Agriculture) Food Guide Pyramid suggests three to five servings of vegetables and two to four servings of fruit every day.


8. Make sure to get fat in your diet.
Even if you are on a weight loss program, polyunsaturated and monounsaturated fats are better for you than saturated. The recommended amount is no more than 30 percent of your total intake of calories.

IPHREHAB ::RUNNING FOR BEGINNERS IN MARATHON RACE

IPHREHAB

RUNNING FOR BEGINNERS IN MARATHON

Running is a simple democratic sport.
To start, you need very little by way of equipment. You don't need an opponent or a team. You don't even need specific skills for taking up jogging as a first step to marathon running.

It all depends on what you want to get out of your running. Approach it in the right way and you will not only have fun, but running will increase your general well-being, will tone your body, give you a healthier complexion and a sunnier outlook to life. Above all, ask experts and novices and all in unison will agree that these benefits pale against the entirely intangible high one gets from finishing a marathon!

You have probably met an individual experiencing post-marathon euphoria. They're the ones who can't walk without a frown due to extreme exertion, but are nevertheless wrapped in a great feeling of achievement, which comes from having dared and succeeded. The achievement makes one feel different inside, think differently and more positively about one's self.
So while there's plenty of magic about the marathon event, there's no special secret about the people who run marathons. They are you and me.

THE FIRST STEP
Your mind is perhaps more important than you realize at this stage.
All runners new or old, fast or slow, have the same decision to make again and again - Get up, and get out there on the road. Many a times a nagging voice in the mind keeps saying, "Let's have a rest day today, it won't matter."
The toughest step is to take the 'first' step.

BEFORE YOU RUN (A MEDICAL ADVICE)
If you have any lingering doubts about your health, or if you have not exercised for a long time or if you have weight or blood pressure problems, ask for medical advice.

RUNNING WITH YOUR BUDDY
It's fun to run together. Running buddies support and help each other to keep going. And importantly, when you know someone is waiting for you, you are less likely to skip the run!

RUNNING GEAR
Running shoes:You need firm cushioning to protect your feet and the rest of your body from the damaging impact of running on the road.
There is no such thing as a single 'best buy.' There are many models of shoes for the simple reason that "no two pairs of feet are the same". There is the shape of your foot to consider - that's called getting the right 'fit.' Ask for road training - running shoes. Make sure there is 'arch support.'

Selecting your running shoes

  • While trying your shoes on, make sure to wear the socks you will be wearing while running.
  • Walk and jog in the shop in a number of shoes to get the feel of them in action.
  • Buy late in the afternoon when your feet are slightly swollen from the day's activities.
  • Look for a comfortable fit. There should be one finger-space (about half inch) between your big toe and the shoe, so your toes can wriggle inside.
  • Get good cushioning at the heel.
  • Look for a padded arch support, soft inner of the shoe and padded tongue.
  • The shoe should not be stiff: you should be able to bend it at the centre - it shows flexibility.
  • The sole of the shoe should be wide enough to support the foot.

Clothing:

  • T-shirts or running vests: make sure they are not too tight at the neck and under the armpits. Nor should it be too thick as it is hot and humid in India. A collarless shirt is less restrictive; dry-fits or cottons are best.
  • Shorts: Best are cotton/nylon mixtures or dry-fit. Better to avoid pure nylon. Make sure you are able to raise one leg so that the thigh is parallel to the floor below.
  • Pants: Cotton pants are more absorbent and tights are good too.
  • Sports bras for women are advisable.
  • Socks: Cotton or dry-fit socks are better for sweat absorption. Special socks with extra cushioning are also available.

WARMING UP
The warm-up is important as cold muscles are more easily damaged. It helps prepare your mind to give the right signals to your body - 'you are readying for your run'.

Loosening exercises:

  • Arms: With your feet astride, raise your arms above your head and move them in a circular fashion away from the body. Keep your body upright, swing both arms forward, then in reverse direction a few times. Then swing your arms sideways together, move your neck and head in the same direction.
  • Forward bending: With your feet together, bend forward and touch your toes, then ease your back upwards and repeat a few times. Do not jerk - you might pull a muscle.
  • Side bending: With your feet astride and hands resting on your hips, lean deep to the left, going down as much as possible, then return to the upright position and repeat on the other side. Do this three to four times.
  • Stretch your calf muscles: Take your right leg in front of you, point your toes up, bend forward and hold your toes. Do not bend the knee. Repeat with the left leg. Do this about two to three times.
  • Quadriceps stretches: Stand on your right leg. Hold your left ankle in your left hand and pull it up towards your butt until you feel the stretch on the front of your thighs. Repeat the same on the left leg.
  • Ham string stretches: Stand facing a table or a parapet (or something you can raise or rest your leg on), raise your left leg and place the heel on the table, then lean forward, hold for a while, and repeat the same on the other leg.

IPHREHAB: 15 Immune Boosting Foods

IPHREHAB
15 Immune Boosting Foods


Elderberry
An old folk remedy, extract from these dark berries appears to block flu viruses in test tube studies. And a few small studies done in people show it may help you recover more quickly from flu. But scientists caution that further study is needed. The fruit itself is rich in antioxidants and may also have the ability to fight inflammation.

Button Mushrooms
Don't dismiss the lowly mushroom as nutrient poor: It has the mineral selenium and antioxidants. Low levels of selenium have been linked to increased risk of developing more severe flu. And the B vitamins riboflavin and niacin, found in these mushrooms, play a role in a healthy immune system. Animal studies have also shown mushrooms to have antiviral, antibacterial, and anti-tumor effects.

Acai Berry
Hawked as a "super food" along with produce like blueberries, the little acai berry's dark color signals that it is high in antioxidants called anthocyanins. While the acai is not scientifically linked to specific disease- or illness-fighting ability, antioxidants may help your body fight aging and disease. Acai berries can be found most often in juice or smoothie form, or dried and mixed with granola

Oysters
Aphrodisiac? Immune boosters? Maybe both, thanks to the mineral zinc that's found in oysters. Low zinc levels have been associated with male infertility.  And zinc appears to have some antiviral effect, although researchers can't explain why. However, they do know it is important to several immune system tasks including healing wounds

Watermelon
Hydrating and refreshing, ripe watermelon also has plenty of a powerful antioxidant, glutathione. Known to help strengthen the immune system so it can fight infection, glutathione is found in the red pulpy flesh near the rind.

Cabbage
This is another source of immune-strengthening glutathione. And cabbage is easy and inexpensive to find during the winter months when it's in season. Try adding cabbages of any variety (white, red, Chinese) to soups and stews to sneak in extra antioxidants and boost your meal's nutritional value.

Almonds
A handful of almonds may shore up your immune system from the effects of stress. A recommended 1/4 cup serving carries nearly 50% of the daily recommended amount of vitamin E, which helps boost the immune system. And they have riboflavin and niacin, B vitamins that may help you bounce back from the effects of stress.

Grapefruit
Grapefruits have a good amount of vitamin C. But science has yet to prove that you can easily get enough vitamin C through foods alone, without supplementation, to help treat cold and flu. However, grapefruit is packed with flavonoids -- natural chemical compounds that have been found to increase immune system activation.  Dislike grapefruits? Try oranges or tangerines.

Wheat Germ
Wheat germ is the part of a wheat seed that feeds a baby wheat plant, so it is full of nutrients. It has zinc, antioxidants, and B vitamins among other vital vitamins and minerals. Wheat germ also offers a good mix of fiber, protein, and some good fat. Substitute wheat germ for part of the regular flour called for in baked goods and other recipes.

Low-Fat Yogurt
A daily cup may reduce your chances of getting a cold.  Look for labels listing "live and active cultures." Some researchers believe they may stimulate your immune system to fight disease. Also look for vitamin D. Recent studies have found a link between low vitamin D levels and an increased risk of cold and flu.

Garlic
Garlic offers several antioxidants that battle immune system invaders. Among garlic's targets are H. pylori, the bacteria associated with some ulcers and stomach cancer. Cooking tip: Peel, chop and let sit 15 to 20 minutes before cooking to activate immune-boosting enzymes. 

Spinach
Known as a "super food," spinach is nutrient-rich.  It has folate, which helps your body produce new cells and repair DNA. And it boasts fiber, antioxidants, such as vitamin C, and more. Eat spinach raw or lightly cooked to get the most benefit.

Tea
Green or black? Both are loaded with disease-fighting polyphenols and flavonoids. These antioxidants seek out cell-damaging free radicals and destroy them. Caffeinated and decaf work equally well.

Sweet Potato
Like carrots, sweet potatoes have the antioxidant beta-carotene, which mops up damaging free radicals. Sweet potatoes also boast vitamin A, which is linked to slowing the aging process and may reduce the risk of some cancers.

Broccoli
Easy to find at the grocery store and incorporate into meals, broccoli is an immune-boosting basic. One study reported a chemical in broccoli helped stimulate the immune systems of mice. Plus, it's full of nutrients that protect your body from damage.  It has vitamins A, vitamin C, and glutathione.  Add some low-fat cheese to round out a side dish with immune-enhancing B vitamins and vitamin D.

Friday 9 March 2012

IPHREHAB: APPROACH FOR NEUROGENIC DISORDER TREATMENT

IPHREHAB
APPROACH FOR NEUROGENIC DISORDER TREATMENT

Approach for neurogenic disorder treatment 
With the above in mind, I felt the need to produce an approach that is in some ways uniquely useful to the clinician. 

The approach is therefore characterized by the following:
1. links between mechanics and physiology of the nervous system
2. integration of neurodynamics with musculoskeletal functions
3. a new movement diagram that enables the clinician integrate musculoskeletal and neural mechanisms
4. a new system for determining the kind and extensiveness of examination and treatment based on
neurodynamics and neuropathodynamics
5. the concept of neurodynamic sequencing and various options in assessment and treatment
6. new diagnostic categories of specific dysfunctions based on neuropathodynamics
7. treatment progressions derived from the above.

Nevertheless, it is common for therapists to diagnose more frequently the problems they have recently learned about, which raises the possibility of false diagnosis due to raw enthusiasm. At all times, the reader will realize that clinical neurodynamics is only one aspect of management of the person in pain and all other relevant information should be included in clinical decision making. For instance, the existence of a neural problem does not necessarily mean that a treatment with a neurodynamic technique is warranted. This could be because other treatments may attack the causative mechanisms more effectively or neurodynamic application may be contraindicated. Clearly, the biopsychosocial approach to neural problems will place this
book in its rightful place as just a modality of treatment that will be effective in some patients and not in
others.

Clinical neurodynamics is for clinicians dealingwith musculoskeletal disorders with peripheral neurogenic pain mechanisms, including those of the nerve root and peripheral nerve. There is no assumption that all problems are as such, or that the treatments presented in this book act only on peripheral mechanisms. The clinician will naturally and responsibly establish that it is appropriate to treat patients with clinical neurodynamics before doing so.

IPHREHAB: NEUROGENIC DISORDER TREATMENT

IPHREHAB

NEUROGENIC DISORDER TREATMENT

Neurogenic disorders are common and their incidence is probably underestimated (Bennett 1997).
With many recent developments in their management, it is merciful that they can now be treated with non-invasive physical methods.

The notion of adverse neural mechanics has been present for many
years and probably longer than we know. 
Wittingly or unwittingly, the first known description of a neurodynamic
test was on the Edwin Smith Papyrus by Imhotep in 2800 BC, in which a leg straightening manoeuvre was performed in the diagnosis of low back pain in workers injured whilst building the Egyptian pyramids (Beasley 1982; Dyck 1984).

However, between then and now, much has happened and it is fascinating to note that, in addition to the neurodynamic tests for the lower quarter, the three major tests for the upper limb nerves (median, radial and ulnar) had been documented and illustrated
pictorially by the 1920s and 1950s (Bragard 1929; Von Lanz & Wachsmuth 1959). Their antitension counterpart postures were also illustrated
next to these neurodynamic tests.

In the context of therapy, neural mobilization has undergone massive development, particularly in the last thirty-five years since Gregory Grieve, Geoffrey Maitland, Robert Elvey and David Butler published
their work. Such an awareness of mechanical function of the nervous system has developed to the point where, for therapists dealing with pain and the musculoskeletal system, proficiency in neurodynamics has become a standard requirement. 


Nevertheless, an author whose work passed relatively unnoticed was Grieve (1970). The reason this paper is important is that in it Grieve commented on, for the first time that I am aware of in the physiotherapy literature, the notion of sensitivity of neural tissues being a key factor in whether they produce symptoms. He remarked on the possibility that inflamed neural tissues may well be more likely to produce abnormal neurodynamic tests as opposed to those on which pressure was exerted by pathologies such as disc bulges. He also alluded to the possibility that nervous system processing could be a means by which neurodynamic tests might change with spinal manual therapy. These aspects have undergone somewhat of a renaissance and they turn out to be key facets of current thinking in clinical neurodynamics.

Sunday 4 March 2012

IPHREHAB: Embryonic Stem Cell Therapy & Spinal Cord Injury Cure

IPHREHAB:
Embryonic Stem Cell Therapy & Spinal Cord Injury Cure

Traumatic Injury to the Spinal Cord
Traumatic injury to the spinal cord prevents electrical nerve messages travelling to and from the brain. When injured, the substance coating the nerves breaks down, along with cellular damage to the neurons, and the electrical signals short circuit, stopping the signals from reaching their destination. These messages control most functions of the human body, including touch and sensation, muscle movement, bladder control and sexual function. With the loss of these messages, the body is paralysed below the level of injury.

Clearing the Way for Stem Cell Therapy to Re-Grow Spinal Cord Nerves
Just days after the inauguration of President Barack Obama, the FDA decided to clear the way for the world's first study on human embryonic stem cell therapy. Geron Corp, the company behind the research, plans to initiate a clinical trial in patients newly paralysed due to spinal cord injury. Initially, a handful of patients with severe spinal cord injuries will be eligible for injections of specialised nerve cells, designed to enable electrical signals to travel between the brain and the rest of the body. When the cells were administered to rats that had lost control of their hind legs, they regained the ability to walk and run, although with a limp.

As a Phase I trial, the study by Geron will primarily assess the safety of the treatment, which has been under development by Geron Corp. for nearly a decade. Scientists, doctors and patients said they were most eager to see whether low doses of the cells would produce any therapeutic benefit.

Embryonic stem cells are coveted by researchers because they theoretically have the ability to grow into any kind of cell in the body. Even if the experimental therapy in spinal cord therapy doesn't make paralyzed patients walk again, it could still substantially improve their quality of life.

Regenerating Spinal Cord Neurons
To treat spinal cord injuries, scientists first needed to reverse the damage to oligodendrocytes, cells that insulate nerve fibers with myelin so that signals can be transmitted to and from the brain. The hard part was figuring out the complex combination of growth factors and other chemicals that would turn stem cells into oligodendrocyte progenitor cells that could make new myelin.

When this method was tested on rats, seven days after the rat's injury, scientists injected the rats at the site of the injury with the progenitor cells. After four weeks, the rats could walk, run and stand on their hind legs, and their coordination had fully recovered, UC Irvine researchers spent two years studying hundreds of rats to make sure the injections were safe. Pure embryonic stem cells tend to grow into tumors, but the rats showed no such signs for a year after treatment. Blood and urine tests turned up none of the chemicals that would signal a toxic reaction.

Embryonic Stem Cell Therapy Clinical Trials
Geron plans to start a Phase I multi-center trial that is specifically designed to assess the safety and tolerability of GRNOPC1 in spinal cord injury patients with "complete" American Spinal Injury Association (ASIA) grade A subacute thoracic spinal cord injuries.

The selected patients eligible for the Phase I trial must have documented evidence of functionally complete spinal cord injury with a neurological level of T3 to T10 spinal segments and agree to have GRNOPC1 injected into the lesion sites between seven and 14 days after injury.

If the cells are administered sooner, they could be damaged by inflammation from the injury. If doctors wait too long, there might be too much scar tissue for the cells to find room to grow,
Patients will be given a low-dose anti-rejection drug for 60 days to ensure their bodies don't reject the GRNOPC1 cells, even though research indicates that the cells won't be recognized by the human immune system.


IPHREHAB:SPINAL CORD INJURY CURE AND TREATMENT VIA OLFACTORY ENSHEATHING CELLS

IPHREHAB


SPINAL CORD INJURY CURE AND TREATMENT VIA OLFACTORY ENSHEATHING CELLS


Olfactory En-sheathing Cells & Spinal Cord Injury Cure:
Damage to the spinal cord
Damaging the spinal cord prevents nerve messages travelling to and from the brain. These messages control most functions of the human body, including touch and sensation, muscle movement, bladder control and sexual function. With the loss of these messages, the body is paralysed below the level of injury.


Can nerves in the spinal cord re grow after injury?
Repairing damage to the spinal cord is very complex, as there are many spinal neurons killed by not only the initial injury, but in the hours, days and weeks following the accident. More neurons are also killed as the body begins to kill neurons close to the injury site (secondary damage). 


As the nervous system develops in the foetus, some nerves cells are programmed to die after they have finished their usefulness. In a spinal cord injury, this self destructive mechanism is triggered again, and some of the neurons around the injury site begin to self destruct or commit suicide in a process called apoptosis.


During the body's response to an injury to the spinal cord, the body forms an impenetrable scar tissue at the site of the injury which acts as a barrier to any neurons that might be trying to grow. Any neurons which have escaped damage may lose their insulating myelin sheath, and so can’t function and pass messages to and from the brain via the spinal cord.


To repair a spinal cord injury, scientists not only have to solve all the problems above, but would then need to find a treatment which makes the neurons grow in exactly the right part of the spinal cord, and form synapses with exactly the right neurons.


Regenerating spinal cord neurons:
In order to encourage the damaged neurons to grow again, a way needs to be found to stimulate the neurons by introducing growth factors.


One of the most recent discoveries is the olfactory ensheathing cell (OEC), also known as the olfactory ensheathing glial cell (OEGC), which is taken from the lining of the nose.


When the olfactory cells are added to a solution containing a scar reducing compound, and the combined solution is added to a damaged spinal cord in rats, the spinal cord was shown to regenerate resulting in a recovery of sensation and movement. The olfactory ensheathing cells provide an environment that promotes axon growth.
Geoff Raisman and his group in London have found ways of injecting these olfactory ensheathing cells into the spinal cord of humans.


The results have been very encouraging and human trials will begin in collaboration with The Royal National Orthopaedic Hospital, Stanmore. When these olfactory ensheathing cells come in contact with the normally barrier-like astrocytes of the glial scar. ‘It’s almost like they knock on the door and the astrocytes open up’ said Geoff Raisman.


Further research and trials are ongoing which include an enzyme to break down the inhibitory proteoglycans in the glial scar tissue to allow neurons to grow, the use of Schwann cells (from the peripheral nervous system) to encourage nerves to grow, and Olfactory ensheathing cells to ensure the axons could grow out of the graft and back into the spinal cord.

IPHREHAB: Spinal Cord Injury : Quadriplegic and Paraplegic Injuries

IPHREHAB

Spinal Cord Injury : Quadriplegic and Paraplegic Injuries
Paraplegic and quadriplegic (tetraplegic) are terms used to describe the medical condition, for a person who has been paralysed due to a spinal cord injury. This classification depends on the level and severity of a persons paralysis, and how it affects their limbs.
This  provides patient information about acute spinal cord injuries, as well as treatment, symptoms, information on long term rehabilitation issues and peer support, to help improve the quality of life of those affected by a spinal cord injury.

What is a Spinal Cord Injury ?
A spinal cord injury (SCI) is typically defined as damage or trauma to the spinal cord that in turn results in a loss or impaired function resulting in reduced mobility or feeling.
Typical common causes of damage to the spinal cord, are trauma (car/motorcycle accident, gunshot, falls, sports injuries, etc), or disease (Transverse Myelitis, Polio, Spina Bifida, Friedreich's Ataxia, etc.). The resulting damage to the spinal cord is known as a lesion, and the paralysis is known as quadriplegia or quadraplegia / tetraplegia if the injury is in the cervical (neck) region, or asparaplegia if the injury is in the thoracic, lumbar or sacral region.
The spinal cord injury level is usually refered to alpha numerically, relating to the affected segment in the spinal cord, ie, C4, T5, L5 etc.
It is possible for someone to suffer a broken neck,or a broken back without becoming paralysed. This occurs when there is a fracture or dislocation of the vertebrae, but the spinal cord has not been damaged.

What is a Complete and Incomplete Spinal Cord Injury
There are typically two types of lesions associated with a spinal cord injury, these are known as a complete spinal cord injury and an incomplete spinal cord injury. A complete type of injury means the person is completely paralysed below their lesion. Whereas an incomplete injury, means only part of the spinal cord is damaged. A person with an incomplete injury may have sensation below their lesion but no movement, or visa versa. There are many types in incomplete spinal cord injuries, and no two are the same.
Such injuries are known as Brown Sequard Syndrome, Central Cord Syndrome, Anterior Cord Syndrome and Posterior Cord Syndrome.

What is Spinal Cord Injury Rehabilitation
Someone with a spinal cord injury will have a long road of rehabilitation ahead of them, usually at a spinal cord injury rehabilitation centre or spinal injury unit, and it is important that they keep their sense of humor on their bad days to help them maintain a positive attitude.
Generally, paraplegics will be in hospital for around 5 months, where as quadriplegics can be in hospital for around 6 - 8 months, whilst they undergo rehabilitation. Both paraplegics and quadriplegics should have some kind of rehabilitation and physiotherapy before they are discharged from hospital, to help maximise their potential, or help them get used to life in a wheelchair, and to help teach techniques which make everyday life easier.
Disabled sports, and wheelchair based sports can be an excellent way to build stamina, and help in rehabilitation by giving confidence and better social skills. The ultimate reward for many disabled sportsmen and women, is to win at the paralympic games, which will be coming to London in 2012.

Spinal Cord Injury Cure and Treatment
A cure for long term paralysis is still some years in the future, but clinical trials are taking place with Olfactory Ensheathing Glial (OEG) cells and Embryonic Stem Cell based Therapy.
and conservative treatment via physiotherapy and rehabilitation approaches.

Paraplegic and Quadriplegic Discussion Forum
If you have any spinal cord injury related questions, please visit our discussion forums and join in on the many topics there. We will do our best to help you, or at the very least, put you in contact with someone who can if we can't. The discussion forum is intended to be a free flow of information between spinally injured people, carers, and their friends, and everyone is welcome.
Even if you don't have any questions, take a look at the forum anyway, as you may be able offer help and advice to others who have questions.

Quadriplegic, Tetraplegic, Paraplegic and it's Definition
Quadraplegic is derived from two separate words from two different languages, Latin and Greek. The word “Quadra”, meaning “four” which is derived from latin, relates to the number of limbs. “Plegic”, is derived from the Greek word “Plegia”, meaning paralysis.
Put the two together, and you have “Quadraplegia”.
“Tetra” is derived from the Greek word for “Four”. “Para” is derived from the Greek word for "two" Hence: Tetraplegic and Paraplegic.
In Europe, the term for 4 limb paralysis has always been tetraplegia. The Europeans would never dream of combining a Latin and Greek root in one word.
In 1991, when the American Spinal Cord Injury Classification system was being revised, the definition of names was discussed. The British are more aware of Greek versus Latin names. Since Plegia is a greek word and quadri is Latin, the term quadriplegia mixes language sources. Upon review of the literature, it was recommended that the term tetraplegia be used by the American Spinal Cord Association so that there are not two different words in English referring to the same thing.

Saturday 3 March 2012

IPHREHAB : OSTEOMALACIA & RICKETS WITH TREATMENT

IPHREHAB


OSTEOMALACIA & RICKETS

DEFINITION
It is a condition characterised  by defective bone mineralisation.
There is increased bone turnover.
It is usually due to Calcium & Vitamin D deficiency.
Condition is rare in USA, UK..
More common in Arab countries

DEFINITION
Rickets is seen in children before Puberty..
Osteomalacia is adult counterpart of Rickets..

Both have same aetiology :
There is failure or defective mineralisation of newly formed matrix

AETIOLOGY
Diet poor in calcium & Vitamin D
Malabsorption Syndromes Chronic Diarrhoea, Sprue,    Steatorrohoea, 
Tuberculosis of Intestines
Chronic  Renal Failure  

AETIOLOGY
Lack of Sunlight Exposure- Reduced Vit. D Conversion 
Hypophophatemia
Vitamin D Resistance Rickets
There is increased thickness of Osteoid Seams, reduces calcification –mineralisation is defective

VITAMIN D METABOLISM
Ultraviolet Rays 
Skin 7-DHC (dehydrocholesterol)
Vitamin D3
Liver  - converts into 25-hydroxylase
Inactive 25(OH) D3
Kidney- 25(OH) Vitamin D 1-a hydroylase
Biological Active 1,25 (OH)2 D3  
Increases absorption of calcium from gut

CLINICAL PICTURE
Delayed DEVELOPMENT-Short Stature
Decreased Muscular Tone (Hypotonia)
Craniotabes  6-12 years 
Frontal Bossing
Delayed Frontallae Closing
Enlargement of Epiphysis (Rickets Rosary)

CLINICAL PICTURE
Teeth are pitted Caries common
Pot-belly Abdomen
Carpopedal Spasms
Laryngeal Stridor
Tetany may be seen
Bone Pains – Defective spine
Waddling Gait

INVESTIGATIONS
Complete Blood Anaemia Common
Serum Calcium Low
Phosphates usually low 
Alkaline Phosphatase raised
X-ray of bones characterstic changes in children Epiphysis thined & distal end of bone widened SAUCER deformity

INVESTIGATIONS
In Adults bone X-ray may be normal or shows osteoporosis
In Children Pseudofractures & Looser’s zones (Radiolucent bands)  may be seen It affects the ribs, Axilliary border of Scapula, Pubic rami

X-Ray of Rickets
BOWED  LEGS
MANAGEMENT
Calcium 1-2 gm daily
Diet- 1 litre of milk
Vitamin D 60,000 IU (1.5 mg of D3) Daily Orally
For tetany IV Calcium gluconate is given
Response to treatment is excellent

Conservative Management
1.Dietary supplement:
2.Physiotherapy treatment :
 .Gentle range of motion exercise.
 .Gradual weaght bearing training.
 .Prevention from fall and injury.
 .Coordination and reconditioning.
 .Light endurance training.

IPHREHAB : INDIAN EXPERIMENT WITH SPIRITUAL AND ENVIRONMENTAL WELL BEING AND HEALTH

IPHREHAB
WE NEED EMPHASIS ON:
  • DIET
  • LIFE STYLES
  • ENVIROMNTAL POLLUTION
  • ENVIRONMENTAL POLLUTION
  • CALCUTTA TRAGEDY
  • MEHSANA WATER PROBLEM
  • OZONE DEPLETION Please remember both earth summits have failed
INDIAN EXPERIMENT : Kurichioas of Wayanad-an illiterate Tribal Community of Kerala
  • HAVE NO MEDICAL FACILITIES
  • STILL ENJOYS HEALTHY LIFE
  • NO   DIABETES, CANCER OR HYPERTENSION
  • AND THERE ARE MANY CENTENARIANS
INDIAN EXPERIMENT :RURAL AND NUMEROUS URBAN AREA
  • HAVE POSITIVE LIFE STYLE
  • CLEAN  ENVIRONMENTS -  NO POLLUTION
  • SALUBRIOUS CLIMATE
  • HIGH  SECURITY
  • HEALTHY JOINT FAMILY SYSTEM.
INDIAN EXPERIMENT
  • FOOD CONSIST OF RAGI, FRESH VEGETABLES, FRUITS & MEAT
  • THEY DO HARD MANUAL WORK 10 HOURS A DAY
  • HIGHLY RELIGIOUS
  • FOND OF MUSIC & SINGING.
SOME ONE HAS NICELY SAID
NO GOVERNMENT  IS REALLY INTERESTED IN HEALTH & WELFARE OF SOCIETY
RICH & HEALTHY PEOPLE ARE THREAT TO GOVERNMENT
MODERN MEDICINE CAN NOT ACHIEVE HEALTH FOR ALL EVEN BY 3000 AD.

WE   NEED
  • AFFORDABLE MEDICAL CARE MODEL
  • GOOD DRUG POLICY
  • STRICT MEDICAL AUDITING REGARDING ADMISSIONS & INVESTIGATIONS
  • MODIFICATION OF CPA
  • IF YOU DON’T DO ANYTHING
  • OUR MEDICINE WILL DIE LIKE BIG DINOSAURS OF OLD DARWIN TIME
  • IF YOU HAVE ANY TEARS IN YOUR EYES ,SHED THEM NOW
THANK YOU

IPHREHAB: HEALTH IS PHYSICAL, MENTAL, SOCIAL & SPIRITUAL WELL BEING

IPHREHAB
HEALTH IS PHYSICAL, MENTAL, SOCIAL & SPIRITUAL WELL BEING

HEALTH IS NOT MERELY THE BODY FREE FROM DISEASE HEALTH IS PHYSICAL, MENTAL, SOCIAL & SPIRITUAL WELL BEING
  • WE HAVE COMPLETELY FORGOTTEN THE SPIRITUAL PART OF HEALTH
  • WE FEEL THAT ONLY DISEASES ARE TO BE TREATED (TERTIARY CARE) MEDICAL  & SURGICAL
PLEASE REMEMBER
  • PUBLIC HAS LOST FAITH IN DOCTORS
  • DOCTORS BEHAVIOUR IS HIGHLY APPAULING
  • DOCTORS ARE VERY BUSY HAVE NO TIME FOR PATIENTS
  • DOCTORS DON’T TALK  ABOUT PREVENTION OF DISEASE
  • BILLIONS ARE SPENT ON TERTIARY CARE HOSPITAL
  • BUT NOT A SINGLE PENNY ON PRIMARY HOSPITAL
DOCTORS DON’T EXAMINE THEIR PATIENT
  • CLINICAL EXAMINATION HAS BECOME  OBSOLETE
  • INVESTIGATIONS ARE  KING OR MASTER
  • DOCTORS ARE TECHNICIAN         
  • NO MORE PHYSICIANS
  • DOCTORS DO NOT GIVE SERVICE THEY HAVE BECOME BUSINESS PERSON
  • INVESTIGATIONS HAVE ATTENDED ROYAL STATUS
  • TREATMENT IS STARTED ON RESULT OF INVESTIGATIONS
  • NO BODY KNOWS THAT MACHINES CAN BE WRONG
  • ECG’s ARE INTERPRETED BY COMPUTER
  • TMT & ECHO ARE ORDERED WHETHER NEEDED OR NOT
INVESTIGATIONS
  • X-RAYS ARE NOT TO BE DONE. 
  • CT SCAN  ARE ORDERED FOR CLEAR CUT CASE OF TUBERCULOSIS
  • Dr. SAYS THAT EVERY ONE COMES TO THEIR CHAMBER IS ALWAYS  WITH CT SCAN
I FEEL IN ANY CASE DIAGNOSIS DEPEND ON
  • HISTORY:-  IT  FORMS FOUNDATION OF DIAGNOSIS
  • CLINICAL EXAMINATION IS LIKE CONSTRUCTION OF BUILDING
  • INVESTIGATIONS ARE LIKE DECORATIVE PIECES
INVESTIGATIONS
  • DAILY NEW TESTS ARE BEING  ADDED SUPPOSED  TO BE SUPERIOR THAN PREVIOUS ONE.
  • NEW EQUIPMENTS  ARE ADDED IN GEOMETRICAL PROPORTION.
  • THEY ARE ALL DUMPED IN THIRD WORLD COUNTRIES - SOUTH EAST ASIA
  • INVESTIGATIONS  ARE GLORIFIED.
THERE  IS NO DRUG POLICY
  • SPURIOUS DRUGS  MARKET IS WORTH MORE THEN  4000 CRORES
  • ANTIBIOTICS ARE MISUSED
  • SO ARE STEROIDS
  • QUACKS ARE FLOURISHING UNDER NAME OF ALTERNATIVE MEDICINE

(DR.ANANT PHODKE THESIS Excellent Study Of Drug Supply & Use
50% of drugs prescribed are irrational or have no connection to disease
He short listed 27 Essential Drugs for 90% of General Diseases)


I BELIEVE IN OLD SAYING

  • IF YOU THROW ALL THE  MEDICINES INTO THE THE SEA 
  • IT WILL BE GOOD FOR HUMAN BEINGS AND BAD FOR FISH.